Description Usage Supplement Facts a synergistic blend of botanicals and nutrient cofactors to enhance mood* a valuable addition to any stress management plan* enhances mood* nutrients and botanicals for neurotransmitter (brain chemical) support* non-habit forming Deproloft-HF is a multi-faceted formula designed to safely enhance mood and cognition.* It combines several known mood-enhancing nutrients and botanicals, such as L-tyrosine and 5-HTP, with other key ingredients, including Rhodiola, Eleutherococcus, and PharmaGABA, to promote healthy neurotransmitter and adrenal function.* Deproloft-HF is "Hypericum free." Hypericum (St. John's wort) is a known inducer of cytochrome p450 3A4 (CYP3A4) and thus can reduce blood levels of medications that are metabolized via this enzyme. Because it does not contain Hypericum, Deproloft-HF is suitable for patients who are taking medications that are metabolized by CYP3A4.* Low serum and red blood cell concentrations of vitamin B12 and folate can have an adverse effect on mood.* Vitamin B12 supports healthy neurological function and red blood cell formation, two factors that can enhance overall mood and stress management.* Deproloft-HF contains 5-MTHF, the active form of folate. Eleuthero (Eleutherococcus senticosus) is a well-known adaptogen and is included in Deproloft-HF to provide general adrenal support.* Gamma aminobutyric acid (GABA), an inhibitory neurotransmitter that balances excessive excitatory responses in the brain, is included to help allay stress and support a calm state of mind.* GABA is provided as the patented, all natural-source PharmaGABA. Deproloft-HF is safe and effective for mood enhancement and a valuable addition to any stress management plan.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Suggested Use Take 2 capsules two times daily or as recommended by your health-care practitioner. ALLERGY WARNING Deproloft-HF is contraindicated in an individual with history of hypersensitivity to any of its ingredients. Iodine may occasionally cause an allergic reaction in some individuals. PREGNANCY WARNING If pregnant, nursing, or trying to conceive, consult your health-care practitioner before using this product. INTERACTIONS 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate. Tyrosine is contraindicated in individuals taking an MAO inhibitor antidepressant medication. 5-Hydroxytryptophan should be used with caution in an individual currently being treated with an SSRI, MAO inhibitor, or other antidepressant medication. ADDITIONAL WARNINGS Vitamin C can cause diarrhea in some individuals in large doses, which can vary from person to person and resolves when the amount is reduced. SUPPLEMENT FACTS Serving size: 2 capsules Servings per container: 60 Ingredients Amount %DV Vitamin C (as Ascorbic Acid) 250 mg † Vitamin B6 (as Pyridoxal 5'-Phosphate) 5 mg † Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)*** 400 mcg † Vitamin B12 (as Methylcobalamin) 550 mcg † Pantothenic Acid (as Calcium Pantothenate) 130 mg † Iodine (as Potassium Iodide) 68 mcg † L-Tyrosine 200 mg † 5-Hydroxytryptophan 50 mg † Eleuthero extract (root) (Eleutherococcus senticosus) 50 mg † Eleuthero extract (root) (Eleutherococcus senticosus) 50 mg † Rhodiola extract (root) (Rhodiola rosea) 50 mg † * % Daily Values are based on a 2,000 calorie diet.† Daily Value not established. Other Ingredients: Hypromellose (derived from cellulose) capsule, Leucine, MagnesiumCitrateLaurate, Silicon Dioxide. ***This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A. **This product uses Pharma Foods International's Gamma-Aminobutyric Acid (PharmaGABA®). PharmaGABA is a registered trademark of Pharma Foods International. Eleutherococcus standardized to Eleutherosides 0.5%. Rhodiola standardized to Total Rosavins 3%.